The correlation of plasma thrombomodulin plasminogen activator inhibitor-1 and endothelial cell injury in septic patients

Abstract

To study the correlation of plasma thrombomodulin (TM), plasminogen activator inhibitor-1 (PAI-1) and endothelial cell injury in septic patients. A total of 100 septic patients were enrolled from February 2017 to February 2019 in Intensive Care Unit (ICU), Union Jiangbei Hospital, Huazhong University of Science and Technology. Subjects were divided into two groups including 50 patients with septic shock and 50 patients with only sepsis. Then 80 healthy subjects were selected as the healthy controls. Plasma TM,PAI-1,circulating endothelial progenitor cells (cEPCs),endothelia-specific molecule-1 (ESM-1),von Willebrand factor (vWF) were tested. The levels of TM and PAI-1 in septic shock group were higher than those in sepsis only group.TM and PAI-1 in all subjects were significantly higher than those in control group (P<0.05). The cEPCs,ESM-1,vWF in septic patients were higher than those in control group, furthermore, all these parameters were extra-higher in septic shock group than in sepsis only group with statistical significance (P<0.05).Correlation analysis suggested that cEPCs, ESM-1 and vWF were positively correlated with TM and PAI-1 (r=0.561, 0.576, P<0.05;r=0.558, 0.603, P<0.05;r=0.677, 0.692, P<0.05).In conclusion, plasma TM and PAI-1 are closely related to the severity of endothelial cell injury in patients with sepsis. The more serious the damage of endothelial cells is, the higher the TM, PAI-1,cEPCs,ESM-1 and vWF levels are, which could be criterion for treatment evaluation.