The Correlation of Plasma Sirt 1 Level and Frailty Degree in The Elderly Outpatients

Abstract

Background: Frailty is a syndrome related to the physical aging process and is characterized by a vulnerability to health decline. Sirtuin 1 (SIRT1) plays a crucial role in weakness, especially in the elderly, serving as a protective factor against frailty. The aim of the study determine the correlation between plasma SIRT 1 level and frailty degree in the elderly outpatientsMethods: This research employed a cross-sectional methodology, involving the observation or measurement of 118 elderly subjects selected through non-probability sampling, Comprehensive medical records were collected, encompassing demographic data such as age, gender, formal education, ethnicity, caregiver status, and marital status. The frailty scale was employed, where 0= robust, 1-2= pre-frailty, and 3-5= frailty. For genetic analysis, 3 cc of blood was collected using the DNA isolation Kit from Promega. Results: Pearson correlation analysis indicated no significant relationship between plasma SIRT1 levels and the presence of positive fertility (r=0.177). However, the F-test revealed a simultaneous and significant association between plasma SIRT1 levels and frailty with a significance level of 0.036 (p < 0.05). The data from the ANOVA test predominantly showed that the frail group had plasma SIRT1 levels slightly above the pre-frail category (>50 ng/ml). Conclusion: There is no significant relationship between plasma SIRT1 levels and frailty scale, while the F-test suggests a simultaneous significant association between plasma SIRT1 levels and frailty