Abstract
BackgroundBy analyzing the clinical features and risk factors in female patients with musculoskeletal symptoms of Southwest China, this report presents the initial analysis of characteristics in this region and compared with international evaluative criteria.MethodsDiagnosis of osteoporosis (OP) was made in female hospital patients age ≥ 18 years admitted from January 1998 to December 2008 according to WHO definition. Case data were analyzed by symptoms, age, disease course and risk factors to reveal correlation with diagnosis of OP. Logistic regression was used to identify the risks of osteoporosis.ResultsA total of 4382 patients were included in the analysis of the baseline characteristics, among which 1455 in the OP group and 2927 in the non-OP group. The morbidity of OP is significantly increased in females' ≥ 50 years. Both groups had symptoms related to pain and numbness; no significant difference was found in reported upper and lower back pain, or leg pain between two groups (p > 0.05). Neck, shoulder and arm pain, leg and arm numbness were more common in the non-osteoporosis group (p < 0.05, OR < 1, and upper limit of 95% CI of OR < 1). Hypertension, diabetes, hyperostosis were major risk factors for the patients with OP. The most common lifestyle-related risk factors for osteoporosis were smoking, body mass index, lack of physical activity and menopause.ConclusionsThe present study offers the first reference data of the relationship between epidemiologic distribution of osteoporosis and associated factors in adults Chinese women. These findings provide a theoretical basis for its prevention and treatment in developing country.
Highlights
By analyzing the clinical features and risk factors in female patients with musculoskeletal symptoms of Southwest China, this report presents the initial analysis of characteristics in this region and compared with international evaluative criteria
Exclusive criteria included: 1) diseases which interfere with bone or calcium metabolism; 2) hepatic or renal inadequacy; 3) taking medicines which could interfere with bone or calcium metabolism; 4) limited mobility such that the patient could not position for the bone density test; and 5) secondary (i. e. steroids, plasmocytoma, or renal) osteoporosis
Results from Bmd Measurements According to osteoporosis is defined as a T-score of less than -2.5 standard deviation (SD) and osteopenia denotes a T-score of -1 to -2.5 SD, Table 2 shows the results of the dual-energy x-ray absorptiometry (DEXA) measurements and the proportion of patients who had osteoporosis, osteopenia and normal bone mineral density (BMD) at same skeletal sites
Summary
By analyzing the clinical features and risk factors in female patients with musculoskeletal symptoms of Southwest China, this report presents the initial analysis of characteristics in this region and compared with international evaluative criteria. The optimal method is the use of clinical risk factors for fractures together with DXA to diagnosis and evaluation of patients with osteoporosis in 2002 [6] At present, The FRAX® tool has been developed by WHO to evaluate fracture risk of patients [7]. It is based on individual patient models that integrate the risks associated with clinical risk factors as well as bone mineral density (BMD) at the femoral neck. These methods were not widely applied in developing countries due to lack certain information channel
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