THE CORRELATION OF LIVER FIBROSIS SEVERITY WITH ESTIMATED GLOMERULAR FILTRATION RATE IN NON-ALCOHOLIC FATTY LIVER DISEASES

Abstract

Background: The mechanism that linked Non-Alcoholic Fatty Liver Diseases (NAFLD) and Chronic Kidney Diseases (CKD) is still difficult to determine what specific processes are underlying, but several studies have shown that NALFD and CKD have the same cardiometabolic and pathomechanical risk and this is related to an increase in inflammatory factors and homeostatic plasma, hyperuricemia, decreased insulin-like levels growth factor-1 (IGF-1), endothelial dysfunction and oxidative stress biomarkers Methods: This was an observational study with a cross-sectional design. 130 Subject were man and woman aged from 18 – 60 years old with abdominal ultrasound result fatty liver in Wahidin Sudirohusodo hospital and Hasanuddin University Hospital, Makassar Indonesia. Results: Among 130 subjects with NAFLD, mostly subject were man (56,9%), age 40-59 years old ( 51,6 %), obese ( 72,3%), Based on GFR the proportion of the subject mostly categorizes as Stage 1 CKD (GFR 90 ml/minutes/1,73m2) is 44, 6 % and liver fibrosis severity mostly categorizes as F0-F1 ( No fibrosis ) is 56,9 %. The proportion of higher GFR (CKD stage 1-2, GFR 60 – 90 ml/minutes/1,73m2 ) was found in the Non fibrosis group than in fibrosis group ( 77,0% vs 64,3 % p >0,005 ) and The proportion of Lower GFR (Stage 3-4 CKD, GFR 15-59 ml/minutes/1,73m2 ) was found higher in fibrosis than non-fibrosis ( 35,7% vs 23,0 % p > 0,005 ). Conclusion: NAFLD Subject with severe liver fibrosis had lower eGFR.