The correlation of gastroparesis and postprandial blood glucose in elderly patients with type 2 diabetes mellitus

Abstract

Objective To investigate the relationship between gastroparesis and PBG in elderly patients with T2DM. Methods Eighty patients were devided into 2 groups: non-elderly DM group (n=22, <60 years old) and elderly DM group (n=58, ≥60 years old). Twenty health participants were used as the control group. Half time gastric emptying of liquid and solid (T1/2), fasting blood sugar, 1 h, 2 h and 3 h PBG, HbA1c and 24 h urine protein were evaluated by SPECT technics. Results Half time gastric emptying of solid (T1/2) of non-elderly DM group and elderly DM group were significantly higher than control group (t=3.56、9.36, P<0.05 or 0.01). The delay rate of solid phase of elder DM group is significantly higher than non-elderly DM group (t=5.21, P<0.05). T1/2, fasting blood sugar, 2 h and 3 h PBG, HbA1c and 24 h urine protein of elderly DM group is significantly higher than non-elderly DM group (t=2.67、3.12、3.43, P<0.05 or 0.01). The peak time of blood sugar of elder diabetics was in 3-hour after meals. Conclusion Diabetic gastroparesis is a common chronic complication of T2DM, the incidence of gastroparesis is high. Doctors should pay attention to the delayed peak time of PBG. Key words: Diabetes mellitus, type 2; Gastroparesis; Gastric emptyinge; Standard meal; SPECT imaging technics