The correlation of distal latency and esophageal motility under esophageal high resolution manometry in gastroesophageal reflux disease

Abstract

Objective To investigate the relationship between esophageal motility and distal latency （DL） in gastroesophageal reflux disease （GERD） using high resolution manometry （HRM）. Methods A total of 51 GERD patients underwent HRM and 24 h-esophageal pH monitoring. According to the HRM to- pography （characterized as either break peristalsis or normal esophageal movement） , all GERD patients were divided into two groups ： hypomotility group（ n = 28 ） and normal group（ n = 23 ）. Fourteen non-GERD con- trols were enrolled. The monitoring results were analyzed. Results The HRM DL of 28 esophageal hypomotility patients（54. 9%, 28/51 ）were the longest（7.27± 1.44）s. Patients with normal peristalsis also had longer latency （6. 70± 1.41 ） s than the non-GERD controls （5.86 ± 0. 96 ） s. All the differences were statisti- cally significant（P 〈0. 01 ）. DCI of hypotensive peristalsis patients（712.49 ± 703.10）mmHg · s· cm was lower compared with the other groups [ （ 1 285.85 ±850. 83 ） mmHg · s· cm, （ 1 109. 74± 611.70） mmHg · s· cm] （P 〈 0. 01 ）. Other indicators such as LES pressure, CFV and IBP showed no significant differences among groups （ P 〉 0. 05 ）. Conclusion Esophageal manometry of GERD patients indicates that esophageal hypomotility is accompanied with prolonged DL. Because DL of all GERD sufferers are extended, esophageal dysmotility has great implications for GERD＇s development. Key words: Gastroesophageal reflux disease; High resolution manometry; Distal latency; Esophageal motility