The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction

Abstract

This thesis aims to discuss the correlation of blood lipid and its ratio, Cystatin C(CysC) and Homocysteine (Hcy) of thyroid dysfunction patients, who are hyperthyroidism, subclinical hyperthyroidism, hypothyroidism and subclinical hypothyroidism. The authors choose each 60 patients of four groups of thyroid dysfunction and the control group to measure the serum TH, blood lipid, CysC and Hcy and calculate and analyze blood lipid ratio. As a result, on the one hand, TC, TG, LDL-C of hyperthyroidism and subclinical hyperthyroidism group are obviously lower than the control group, TC/HDL-C and TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C of hyperthyroidism are significantly lower than the hyperthyroidism and the control group. LDL-C/HDL-C, and TC/HDL-C and TG/HDL-C of subclinical hyperthyroidism significantly reduce, and especially LCI is significant. The followings are LDL-C/HDL-C, nevertheless TC/HDL-C, TG/HDL-C are higher than the control group. On the other hand, TC, TG, LDL-C, TG/HDL-C, LDL-C/ HDL-C, LCI and non-HDL-C of hypothyroidism are prominently higher than the subclinical hypothyroidism and the control group. TC, TG and LDL-C, LDL-C/HDL-C and non-HDL-C of the subclinical hypothyroidism are higher than the control group. HDL-C is lower than the control group. TC has the highest relevance in various kinds of TH and the followings are respectively: non-HDL-C, LDL-C and LCI. CysC of hyperthyroidism and subclinical hyperthyroidism group obviously increases, whereas Hcy decreases. CysC of hypothyroidism and subclinical hypothyroidism group obviously decreases, whereas Hcy increases. According to the results, the authors come to the conclusion that the change of blood lipid ratio of subclinical thyroid dysfunction is more obvious than the index of single blood lipid and the CysC and Hcy also corresponding change. Dynamic monitoring TSH, blood lipid ratio, CysC and Hcy has an important value of transforming from subclinical thyroid dysfunction to clinical dysfunction and prediction of concurrent CVD. Joint detection is expected to become the ideal optimization combination of project.