Abstract
Tumor microenvironment (TME) plays a particularly important role in the progression, invasion and metastasis of cervical carcinoma (CC). Tumor-associated macrophages (TAMs) are significant components of the tumor microenvironment in CC. However, the results of studies on the correlation between TAMs and progression in CC are still controversial. This research aimed to investigate the relationship between TAMs infiltration and progression in CC. A total of 100 patients with CC were included in the study. The correlation between TAMs and clinicopathologic features was studied. Besides, a systematic literature search was conducted from legitimate electronic databases to specifically evaluate the role of TAMs in TME of cervical carcinoma. In the meta-analysis, high stromal CD68+ TAMs density was relevant to lymph node metastasis (WMD = 11.89, 95% CI: 5.30–18.47). At the same time, CD163+ M2 TAM density was associated with lymph node metastasis (OR = 2.42, 95% CI: 1.09–5.37; WMD = 39.37, 95% CI: 28.25–50.49) and FIGO stage (WMD = -33.60, 95% CI: -45.04 to -22.16). This was further confirmed in the experimental study of 100 tissues of cervical cancer. It supported a critical role of TAMs as a prospective predictor of cervical cancer. In conclusion, CD68+ TAM and CD163+ M2 TAM infiltration in CC were associated with tumor progression. And CD163+ M2 TAM infiltration was associated with more advanced FIGO stage and lymph node metastasis in CC.
Highlights
IntroductionRelevant results have been achieved in the field of primary and secondary prevention, it continues to be the second leading cause of cancer deaths in young women, causing 9 people in the 20–39 years group to die per week in developed countries such as the United States [2]
Cervical carcinoma (CC) is one of the most common gynecological tumors [1]
The results showed that there were no statistical significance [weighted mean difference (WMD) = -4.63, 95% confidence interval (CI): (-17.21, 7.95), P=0.47]; [odds ratio (OR) = 0.33, 95% CI: (0.05–2.21), P=0.26], indicating that there was no significant difference in the correlation between CD68+ tumor-associated macrophage (TAM) and different histological grades of cervical cancer (Figure 6B,C)
Summary
Relevant results have been achieved in the field of primary and secondary prevention, it continues to be the second leading cause of cancer deaths in young women, causing 9 people in the 20–39 years group to die per week in developed countries such as the United States [2]. The proportion of patients with locally advanced diseases among CC cases has remained stable in most developed countries [3]. Immunotherapy, as a new method of tumor therapy, is being popularized in clinic. Tumor-associated macrophages (TAMs) are an important part of the tumor microenvironment (TME) [4,5]. They act as immune regulators in TME and are potential targets for immunotherapy of cancer patients [6]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
