The correlation between the SP-B gene T131I polymorphism and respiratory distress syndrome of newborn in the western region of Inner Mongolia

Abstract

Objective To study the relationship between the pulmonary surfactant protein B (SP-B) gene T131I polymorphism and the susceptibility of respiratory distress syndrome (RDS) of newborn. Methods From September 2009 to February 2016, Han premature infants admitted to Affiliated Hospital of Inner Mongolia Medical University were prospectively recruited. Participating infants diagnosed with RDS were assigned to RDS group, and infants without RDS nor infectious diseases were assigned to control group.PCR was used to detect the genotype and allele distribution of SP-B T131I locus. Results A total of 141 cases were recruited to each group. Three genotypes CC, CT and TT were detected on SP-B T131I locus of the premature infants. The distributions of genotype CC, CT and TT in the RDS group were 62.4%, 27.7% and 9.9%, and 50.4%, 35.5% and 14.2% in the control group. No statistically significant differences existed between these two groups (P>0.05). The frequency of allele C in RDS group was significantly higher than the control group (76.2% vs. 68.1%, P<0.05). Conclusion The polymorphism of SP-B C allele in T131I locus may be associated with the RDS of Han premature newborns in the western region of Inner Mongolia. Key words: Respiratory distress syndrome, newborn; Pulmonary surfactant-associated protein B; Genetic testing; Polymorphism, single nucleotide