The correlation between the results of 99m Tc-technetril accumulation and MSCT data in granulomatous lung diseases

Abstract

<b>Aim:</b> To establish the correlation between the radiopharmaceutical&nbsp;(RP)&nbsp;99mTc-technetril accumulation and multislice computed tomography (MSCT) data in patients with granulomatous lung diseases. <b>Materials and methods:</b> We analyzed data obtained using planar single-photon emission computed tomography (SPECT) and results of the study with 99mTc-technetril performed in 61 patients. Out of them 22 (36.1%) were diagnosed with disseminated pulmonary TB (TB), 13 (21.3%) – nontuberculous mycobacteriosis (NTM), 9 (14.7%) – hypersensitivity pneumonitis (HP), and 17 (27.9%) – pulmonary sarcoidosis (PS). We studied the macrophage formula of bronchoalveolar lavage in all patients. <b>Results:</b> In the&nbsp;planar mode accumulation&nbsp;of&nbsp;99mTc-technetril&nbsp;was observed in all TB patients; more significant accumulation was observed in the most affected lung tissue regions detected by MSCT. According to CT data, dissemination of focal changes in the lungs was observed in 76.9% of NTM patients, accumulation of RP was indicated in 61.6% of them. Disseminated lung tissue lesions were observed in 77.8% of HP patients, RP accumulation – in 55.6% of them. Disseminated focal changes were observed in 76.5% of PS patients, RP accumulation – in 52.9% of them. <b>Conclusion:</b> 1) Our research confirms the correlation between the extent of 99mTc-technetril accumulation and the nature of a granulomatous lung disease. 2) According to our data, accumulation of 99mTc-technetril correlates with macrophage activity in the foci detected by MSCT. Our research established the chronic nature of TB in 57.7%, NTM – 85.9%, HP – 59.7%, and PS – 71.3% of patients.