The Correlation between Serum Amyloid A, Mean Platelet Volume, and Creatine Kinase Myocardial B in Acute Coronary Syndrome

Abstract

BACKGROUND: Atherosclerosis causes acute myocardial necrosis and inflammation characterized by increased mean platelet volume (MPV) and serum amyloid A (SAA). Creatine Kinase Myocardial Band (CKMB) is known as myocardial necrosis marker commonly used in daily practice to help diagnosing acute coronary syndrome. AIM: The purpose of this study was to determine the correlation between MPV, SAA, and CKMB in patients with acute coronary syndrome. METHODS: An analytic observational study with a cross-sectional approach was conducted from May to July 2019. This study involved 32 patients with ACS at the Emergency Department of Dr Kariadi Public Hospital. The inclusion criteria of this study were patients with chest pain, aged 30–75 years, and normal body temperature while the exclusion criteria were malignancy, undergoing chemotherapy/radiation, renal failure, hypertension, and liver disease. Examination of CKMB was done using the spectrophotometry method, MPV value was measured using a hematology analyzer, and SAA level was measured using the ELISA method. Statistical test was done using Spearman correlation. RESULTS: The median (min-max) of MPV and SAA values was 9.85 (2.78-11.7) fL and 40.454 (5.879–66.059) μg/ml, while the mean ± SD (min-max) value of CKMB was 115.47 ± 155.97 (10–608) U/L. The correlation coefficient between CKMB level with MPV and SAA levels were r = −0.244 (p = 0.179) and r = 0.442 (p = 0.011), respectively. CONCLUSION: There was a significant positive moderate correlation between CKMB and SAA levels which could be used as a marker of acute inflammation in ACS, whereas inflammatory marker of MPV did not have a significant correlation.