The correlation between serum 25-hydroxyvitamin D and parathyroid hormone levels and orthostatic intolerance in children

Abstract

BackgroundThe role of vitamin D deficiency in cardiovascular disease in children is controversial and less well studied in orthostatic intolerance (OI). ObjectivesThis work was to investigate the correlation between OI and serum 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) levels in children. MethodsThis work reviewed 151 children who were first admitted to the Lanzhou University Second Hospital (LZUSH) during January 2019 ~ August 2020. There were 142 children with OI, including 93 children with vasovagal syncope (VVS), 45 children with postural orthostatic tachycardia syndrome (POTS), and 4 children with orthostatic hypotension (OHT). 87 children who visited the Child Health Management Center of LZUSH in the same period were selected as healthy controls. The 25(OH)D and PTH of all children were detected at the first visit. Results1. Compared with healthy children, 25(OH)D level was significantly decreased in OI children (P < 0.001), but PTH level showed no obvious difference (P = 0.161). 2. Binary logistic regression analysis showed that the 25(OH)D level was the only factor causing OI. Every unit of 25(OH)D increased, the probability of OI decreased by 77.7 % (95 % confidential interval (CI): 0.720, 0.838). ConclusionVitamin D deficiency was very common in children with OI, but whether it was involved in OI needed further research. PTH may not affect the incidence of OI, but further research was also needed.