Abstract
Objective: To investigate the correlation between plasma drug concentration of aripiprazole and its clinical efficacy in the treatment of children and adolescent patients with schizophrenia. Methods: 27 cases of children and adolescent patients with schizophrenia received oral non-fixed dosage of aripiprazole for 8 weeks. The plasma concentration of aripiprazole was determined with High Performance Liquid Chromatography (HPLC). The psychotic symptoms of patients were evaluated with Positive and Negative Syndrome Scale (PANSS) and the adverse reactions were assessed with Treatment Emergent Symptom Scale (TESS). Results: There was no correlation between the plasma concentration of aripiprazole and the reduction rate of PANSS scores at the end of first week (r = 0.201, p > 0.05). A positive correlation between the plasma concentration of aripiprazole and the reduction rate of PANSS scores was found at the end of second week (r = 0.352, p = 0.055), and significant correlations were observed at the end of both fourth and eighth weeks (r > 0.503, p < 0.05). No relationship was found between the oral dosage of aripiprazole and the clinical efficacy. The mean concentration of aripiprazole in effective group was higher than that of ineffective group. The lowest effective concentration of aripiprazole was 285.2 ng/ml and the concentration threshold occurring side effects was 440 ng/ml. Conclusion: The plasma concentration of aripiprazole is correlated with its clinical efficacy in the treatment of children and adolescent patients with schizophrenia symptoms, and the suitable concentration range is 285.2~440 ng/ml.
Highlights
Childhood-onset schizophrenia is rare, it is relatively common for adolescent-onset schizophrenia . [1,2] Safe and effective treatments are the key for the youths
The plasma concentration of aripiprazole is correlated with its clinical efficacy in the treatment of children and adolescent patients with schizophrenia symptoms, and the suitable concentration range is 285.2~440 ng/ml
Studies have shown that aripiprazole treatment of schizophrenia in children and adolescents is relative effective and safe . [7,8] It has been extensively investigated the correlation between steady-state plasma concentration of aripiprazole and clinical outcomes in the treatment of adult schizophrenia . [9,10] the correlation between plasma concentration of aripiprazole and clinical outcomes when used on children and adolescents remains uncertain
Summary
27 cases of children and adolescent patients with schizophrenia received oral non-fixed dosage of aripiprazole for 8 weeks. The plasma concentration of aripiprazole was determined with High Performance Liquid Chromatography (HPLC). The psychotic symptoms of patients were evaluated with Positive and Negative Syndrome Scale (PANSS) and the adverse reactions were assessed with Treatment Emergent Symptom Scale (TESS)
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