The correlation between phosphorylated Histone H3 (PHH3) and p-STAT3 in Meningiomas

Abstract

ObjectiveTo assess the correlation between PHH-3 and STAT-3 in grade I and grade II meningiomas. Patients and methodsMedical records were retrospectively reviewed for all cranial cases which diagnosed and underwent surgery at Bezmialem Vakif University Hospital between 2012 and 2017. All cranial grade I and grade II meningioma patients constituted the core sample for this study. ResultsThis series included 104 (69 female, 35 male) patients, with a median age of 57.3 years. The mean preoperative course was 23.0 ± 40.5 months. The most common symptom was headache (76%) and followed by seizure (24%), weakness (18%) and visual disturbances (14%). Seventy one (68.2%) patients were diagnosed as WHO grade I meningioma and 33 (31.8%) were WHO grade II, grade III meningiomas were excluded from study due to small number of patients. Subtypes of meningioma includes 5 angiomatous (4,8%), 6 fibroblastic (5.7%), 1 meningothelial (0,9%), 11 psammomatous (10,5%), 3 secretory (2,8%), 43 transitional (41,3%) and 33 atypical (31,7%) meningiomas. There is a strong correlation with PHH-3 and Ki-67 (p:0,001>) and mitosis index (p:0,001 > ) although there is no correlation with STAT-3 (p:0,260). There is a strong correlation with STAT-3 and Ki-67 (p:0,013), although there is no correlation with mitosis index (p:0,085) and PHH-3 (p:0,260). ConclusionsIn our study we also obtain same results with Ki-67 and mitotic index, although correlation with PHH-3 and STAT-3 is firstly determined and there was no statistically significant relation were observed. Depends on the STAT-3 cell proliferation feature, inactivation of these pathways may predict new chemotherapies for grade II meningiomas.