Abstract
BackgroundWe aimed to investigate the correlation between the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-neutrophil ratio (PNR), platelet-to-white blood cell ratio (PWR) and 90-day mortality in patients with acute ischemic stroke (AIS).MethodsWe retrospectively included 633 patients with AIS from January 2017 to May 2018. The correlation between each indicator and the degree of neurologic deficit was assessed. Kaplan-Meier survival curves based on blood cell ratios were used to analyze the 90-day survival rate of patients with AIS.ResultsA total of 663 patients with AIS were enrolled, of which 24 (3.6%) experienced recurrence and 13 (2.0%) died. NLR>3.23 (odds ratio; OR = 2.236; 95% confidence interval [CI], 1.472–3.397; P<0.001), PNR<31.14 (OR = 0.471; 95% CI, 0.297–0.749; P = 0.001), and PWR<20.62 (OR = 0.498; 95% CI, 0.309–0.800; P = 0.004) were associated with an unfavorable 90-day prognosis. NLR>3.23, PWR<20.62, and PNR<31.14 were associated with an increased risk of 90-day mortality.ConclusionPNR, PWR, and NLR were associated with the 90-day mortality of patients with AIS. Patients with high NLRs or low PWRs and PNRs may have a greater risk of mortality than other patients. These clinical indicators may help clinicians judge unfavorable prognosis early and implement the appropriate interventions.
Highlights
Acute ischemic stroke (AIS), a common clinical cerebrovascular disease, has high disability, recurrence and mortality rates in China [1]
neutrophil-to-lymphocyte ratio (NLR)>3.23, platelet-to-neutrophil ratio (PNR)
NLR>3.23, PWR
Summary
Acute ischemic stroke (AIS), a common clinical cerebrovascular disease, has high disability, recurrence and mortality rates in China [1]. The main cause of AIS is atherosclerosis [2], in which inflammation plays an important role [3, 4] Leukocytes and their subtypes, as commonly used inflammatory markers in the clinic, are considered to be correlated with infarct volume [5], infarct severity [6], and unfavorable outcomes [7]. Many studies have suggested that peripheral blood cell ratios have critical clinical value as novel biomarkers for predicting stroke [8,9,10]. We aimed to investigate the correlation between the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-neutrophil ratio (PNR), platelet-to-white blood cell ratio (PWR) and 90-day mortality in patients with acute ischemic stroke (AIS)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
