Abstract
Objective To investigate the correlation between thyroid nodules and microalbuminuria in type 2 diabetic mellitus. Methods A total of 270 patients with type 2 diabetes at Tongzhou Branch of Dongzhimen Hospital were enrolled in this retrospective study. Data were collected from the inpatient electronic files between January 2018 and January 2020. The laboratory indexes of the two groups (thyroid nodule group with 172 cases and control group including 98 cases without thyroid nodules) were statistically analyzed by binomial logistic regression analysis and Spearman correlation analysis. Results The proportion of microalbuminuria (MAU) in the thyroid nodule group was larger than that in the control group. Age, serum TT4, and FT4 in the thyroid nodule group were significantly higher compared with the control group. The binary logistic regression analysis indicated that age, sex, FT4, and MAU were the risk factors for thyroid nodule in T2DM patients. Spearman correlation analysis showed that the thyroid nodule was significantly positively correlated with MAU, age, FT4, and TT4. Conclusions MAU might be an independent risk factor for thyroid nodule in type 2 diabetic mellitus.
Highlights
Type 2 diabetes mellitus (T2DM) is a common disease in endocrinology, which is frequently coexisting with thyroid nodules
Insulin resistance (IR), one of the characteristics of type 2 diabetes mellitus (T2DM), has been demonstrated to be a risk factor for TNs in patients with T2DM [3]. yroid function in T2DM patients may be closely associated with microalbuminuria (MAU), which is an early manifestation and one of the important prediction and prognosis of diabetes nephropathy [4]
Abnormal urinary microalbumin in patients with T2DM may be an important indicator for screening thyroid nodules
Summary
Type 2 diabetes mellitus (T2DM) is a common disease in endocrinology, which is frequently coexisting with thyroid nodules. The relationship between T2DM and TNs has been investigated quite intensively. Yroid function in T2DM patients may be closely associated with microalbuminuria (MAU), which is an early manifestation and one of the important prediction and prognosis of diabetes nephropathy [4]. FT3 is reported to negatively correlate with microalbuminuria in T2DM patients independent of other risk factors [5]. Other study has shown that thyroid stimulating hormone (TSH) levels are negatively associated with TN formation [6]. The association between microalbuminuria and thyroid nodules in T2DM has not been clarified. We aimed to investigate the correlation between TN and MAU in patients with T2DM
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