The correlation between endocan and diabetic peripheral neuropathy

Abstract

Objective To investigate the correlation between serum endocan level and risk of diabetic peripheral neuropathy(DPN). Methods A total of 67 patients with type 2 diabetes mellitus (T2DM) were recruited from the Department of Endocrinology in Gansu Provincial Hospital From April 2015 to November 2015. All patients were divided into DPN group (n=25) and simple T2DM group (n=42). Meanwhile, gender and age matched healthy subjects were included as the normal control group(NC group, n=28). Serum endocan was measured by ELISA, and other metabolic parameters were also tested. Pearson correlation analysis, logistic regression analysis and area of receiver operator characteristic (ROC) curve analysis were used to analyze the correlation between endocan level and DPN risk. Results Compared with NC group, the serum level of endocan was significantly increased in simple T2DM group and DPN group(F=24.26, P<0.05). In addition, compared with simple T2DM group, the serum level of endocan in DPN group was markedly higher (t=5.668, P<0.05). Endocan was positively correlated with the course of disease and age(r=0.438, 0.394, all P<0.05). Endocan level, smoking and age were the independent risk factors for DPN(OR=1.692, 9.880, 1.093, 95% CI: 1.279-2.237, 2.039-47.878, 1.024-1.168, all P<0.05). The results of the ROC analysis revealed that the area under ROC curve was 0.824(95% CI: 0.727-0.921, P=0.000). Conclusion Serum level of endocan is related to DPN, and it may be used as a novel biomarker for DPN. Key words: Endocan; Diabetic peripheral neuropathy; Type 2 diabetes mellitus