The correlation between CYP4F2 variants and chronic obstructive pulmonary disease risk in Hainan Han population

Yipeng Ding,Jie Zhao,Xiaoli Zhou,Dongchuan Xu,Qiong Feng,Cibing Wu,Yixiu Yang,Jianfang Liu,Hongxia Yao,Huan Niu,Quanni Li,Ping He

doi:10.1186/s12931-020-01348-6

Yipeng Ding, Jie Zhao + Show 10 more

Open Access

https://doi.org/10.1186/s12931-020-01348-6

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Abstract

BackgroundChronic obstructive pulmonary disease (COPD) is a complex pulmonary disease. Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) belongs to cytochrome P450 superfamily of enzymes responsible for metabolism, its single nucleotide polymorphisms (SNPs) were reported to be involved in metabolism in the development of many diseases. The study aimed to assess the relation between CYP4F2 SNPs and COPD risk in the Hainan Han population.MethodWe genotyped five SNPs in CYP4F2 in 313 cases and 508 controls by Agena MassARRAY assay. The association between CYP4F2 SNPs and COPD risk were assessed by χ2 test and genetic models. Besides, logistic regression analysis was introduced into the calculation for odds ratio (OR) and 95% confidence intervals (CIs).ResultsAllele model analysis indicated that rs3093203 A was significantly correlated with an increased risk of COPD. Also, rs3093193 G and rs3093110 G were associated with a reduced COPD risk. In the genetic models, we found that rs3093203 was related to an increased COPD risk, while rs3093193 and rs3093110 were related to a reduced risk of COPD. After gender stratification, rs3093203, rs3093193 and rs3093110 showed the association with COPD risk in males. With smoking stratification, rs3093144 was significantly associated with an increased risk of COPD in smokers. CYP4F2 SNPs were significantly associated with COPD risk.ConclusionsOur findings illustrated potential associations between CYP4F2 polymorphisms and COPD risk. However, large-scale and well-designed studies are needed to determine conclusively the association between the CYP4F2 SNPs and COPD risk.

Highlights

Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disease
We found that rs3093203 was related to an increased COPD risk, while rs3093193 and rs3093110 were related to a reduced risk of COPD
CYP4F2 single nucleotide polymorphisms (SNPs) were significantly associated with COPD risk

Summary

Introduction

Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disease. The study aimed to assess the relation between CYP4F2 SNPs and COPD risk in the Hainan Han population. Chronic obstructive pulmonary disease (COPD) is a commonly heterogeneous diseases caused by distinct pathophysiological processes, with a high morbidity. In the United States, 75% of COPD cases are diagnosed as smoking-related, but, other occupational or environmental factors such as diesel exhaust and smoke from indoor cooking contributing to the development of COPD [6]. In China, COPD was considered as the third leading cause of death and accounted for over 0·9 million deaths reported in 2013 [7]. Cigarette smoking is considered as the major environmental risk factor for the development of COPD. Individuals varied greatly in their susceptibility to response to tobacco smoking, illustrating that genetic factors played vital role in the incidence and development of COPD. Recent Genome-wide association studies have provided strong evidence for common susceptibility loci for COPD [10,11,12,13]

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