The correlation between brain natriuretic peptide, creatinine and glycosylated hemoglobin in patients with acute heart failure

Abstract

Objective To investigate the correlation between brain natriuretic peptide (BNP) , creatinine (Cr) and glycosylated hemoglobin in patients with heart failure, and to explore the correlation between glycosylated hemoglobin and heart failure. Methods We selected 106 cases with congestive heart failure in the Fuxing Hospital Affiliated to Capital University of Medical Sciences. We tested BNP, serum creatinine level, evaluation of glycated hemoglobin level of patients with heart failure immediately after admission. Results The BNP levels in patients whose glycosylated hemoglobin level more than 6.5% of BNP levels was (1 356.47±398.69 ) ng/L, and significantly higher than (686.27±188.31) ng/L of patients whose glycosylated hemoglobin in normal group (P<0.01) . Serum creatinine level (159.32±42.31) μmol/L in patients whose glycosylated hemoglobin level more than 6.5% was significantly higher than creatinine level (105.32±11.03) μmol/L in glycated hemoglobin normal group (P<0.01) . Conclusions Blood BNP, serum creatinine level in patients with heart failure in the glycosylated hemoglobin level more than 6.5% patients was higher than glycosylated hemoglobin normal level group. The higher glycosylated hemoglobin levels in patients with severe heart failure and poor renal function . The latest glycosylated hemoglobin can be a marker for the risk of heart failure. Key words: Glycosylated hemoglobin; Brain natriuretic peptide; Creatinine