The correlation between 8 kinds of coagulation related indicators and recurrent spontaneous abortion

Abstract

Objective To investigate the correlation between coagulation related indicators and recurrent spontaneous abortion (RSA). Method The lupus anticoagulant factor (LA), antithrombin III (ATIII), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fg), D-dimer (D-D), and platelet count (PLT) were tested and analyzed in 55 cases of RSA, 50 normal pregnant women, and 45 normal non-pregnant women. Results Compared with normal non-pregnant women, ATIII level in 55 cases of RSA was lower, APTT and PT were significantly shorter, FIB and D-D levels were significantly higher; APTT in normal pregnant women was significantly shorter, D-D level was significantly higher, with statistically significant differences (P 0.05). The positive rate of lupus anticoagulant factor in 55 cases of RSA and normal pregnant women were both higher, that in 55 cases of RSA was much higher, with statistically significant differences (P<0.05). Conclusion Pregnancy is a hypercoagulable state, pathologic thrombophilia is one of the causes of RSA. Combined detection of coagulation and anticoagulant indicators is important to RSA. Key words: Recurrent spontaneous abortion; Lupus anticoagulant factor; Coagulation function