The correlation analysis of the cochlear hydrops degree found by MRI angiography with Meiniere's disease classification

Abstract

Objective:To investigate the correlation between the levels of cochlear hydrops with the clinic classification of Meniere's disease(MD).Method:3D-FlAIR MRI was performed 24 hours after intratympanic injection of 8-fold diluted Gadopentetate Dimeglumine in 31 patients with unilateral MD. We evaluated the levels of cochlear hydrops and further analyzed the correlation between the levels of cochlear hydrops and thresholds of pure tone audiometry and clinic classification of MD. Result:MRI image clearly distinguished perilymph from endolymph in the labyrinth. The images showed different levels of enhancement of perilymphatic fluid spaces. In the 31 patients, obvious signs of endolymphatic hydrops were found, including 4 cases of level 0, 6 cases of level 1, 11 cases of level 2 and 10 cases of level 3. Their average hearing threshold was(54.37±3.88)dB HL. The levels of cochlear hydrops were significantly correlated with pure tone audiometry thresholds （r=0.636，P<0.01） and MD classification(r=0.516,P<0.01). None of the patients after intratympanic injection complained about discomfort or happened with any complications such as eardrum perforation, infection, and so on. Conclusion:The degree of endolymphatic hydrops based on MRI in MD patient has significant correlation with the pure tone audiometry and classification of disease. The examination can act as an objective index for MD diagnosis.