Abstract
Objective To study the expression of Ki-67 (a kind of proliferation cell nuclear antigen),cyclooxygenase-2 (COX-2) in breast cancer before neoadjuvant chemotherapy,and its correlation with the changes of maximum standarded uptake value (SUVmax).Methods In a prospertive trial,18F-FDG PET-CT were performed in 19 women with primary breast cancer before and after the first and second cycle of neoadjuvant chemotherapy respectively,the changes of SUVmax were computered.Divided the patients into different groups according to the Ki-67 and COX-2 expression,then compared the rate of change of SUVmax in different groups.Results There was no correlation between the changes of SUVmax after chemotherapy and the expression of Ki-67,COX-2 before neoadjuvant chemotherapy.Conclusions The expression of Ki-67 and COX-2 before neoadjuvant chemotherapy were unable to sufficiently explain the changes of 18F-FDG uptake during the chemotherapy process.The metabolic changes were most likely explained by a complex interaction between cellular energy demand and tumoral microenvironment. Key words: Breast neoplasms; Chemotherapy, adjuvant; Ki-67 antigen; Cycloocygenase 2; Positronemission tomography; Tomography, X-ray computed
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