The Correction of Focal Point Displacement Caused by the Refraction of the Beams in High-Intensity Focused Ultrasound

Abstract

Nowadays, high-intensity focused ultrasound (HIFU) as nonionizing radiation is used for cancer treatment. Basically, the function of HIFU is similar to conventional ultrasound. Ultrasound beams are perverted when crossing the border of different environments. This decreases the beam's focus within the tumor and may induce damage to the normal tissues. In this study, we aim to develop appropriate algorithms for correcting the focal point displacement duced by the beam's refraction. First, the level of displacement due to difference in two specific tissues was calculated for one element of the transducer and, then, it extended to all of the elements. Finally, a new focal point was calculated, which is considered as a desired focal point of the transducer in which the maximum temperature occurs. Designed algorithms were implemented in MATLAB software. A HIFU simulator (by the Food and Drug Administration of US) was used to simulate HIFU therapy. The proposed algorithm was tested on four models with two layers of tissue. Results illustrated the use of proposed algorithm results for 78% correction in the focal point displacement. In addition, it was noted that a part of this displacement was caused by the absorption of the beam in the tissues. The proposed algorithm can significantly correct the focal point displacement in HIFU therapy and consequently prevent damage to the normal tissues.