Abstract
Mesenchymal (stem) stromal cells (MSC) can be a therapeutic alternative for COVID-19 considering their anti-inflammatory, regenerative, angiogenic, and even antimicrobial capacity. Preliminary data point to therapeutic interest of MSC for patients with COVID-19, and their effect seems based on the MSC’s ability to curb the cytokine storm caused by COVID-19. In fact, promising clinical studies using MSC to treat COVID-19, are currently underway. For this reason, now is the time to firmly consider new approaches to MSC research that addresses key issues, like selecting the most optimal type of MSC for each indication, assuming the heterogeneity of the donor-dependent MSC and the biological niche where MSC are located.
Highlights
The emergence of the coronavirus pandemic (SARS-CoV-2), due to its unusual and unforeseen virulence, is demanding new strategies from all areas of society around the world
Mesenchymal (stem) stromal cells (MSC) and its conditioned medium or extracellular vesicles (EVs) obtained from MSC strongly emerge as possible therapeutic alternatives, due to their anti-inflammatory, regenerative, pro-angiogenic, anti-fibrotic and antimicrobial capacities
The first clinical trial on the safety and aerosol tolerance of CMM-exosomes from adipose tissue derived (AD)-MSC has already been launched on March 2020 at Ruijin Hospital in Shanghai (China
Summary
The emergence of the coronavirus pandemic (SARS-CoV-2), due to its unusual and unforeseen virulence, is demanding new strategies from all areas of society around the world. Sometimes these defense mechanisms overreact in the presence of harmful agents, causing an inflammatory hyper-response that becomes more harmful that the initial aggression, due to its devastating action on tissues In this sense, the over-activated pulmonary macrophages and the consequent “storm” of inflammatory cytokines have been identified as one of the key elements in the fatal outcome of coronavirus infection. The over-activated pulmonary macrophages and the consequent “storm” of inflammatory cytokines have been identified as one of the key elements in the fatal outcome of coronavirus infection This over-reactive response against a viral infection is a catastrophic situation and available therapeutic agents are not demonstrating the necessary efficacy. MSC and its conditioned medium or extracellular vesicles (EVs) obtained from MSC strongly emerge as possible therapeutic alternatives, due to their anti-inflammatory, regenerative, pro-angiogenic, anti-fibrotic and antimicrobial capacities
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