Abstract
Evaluation of estrogen receptor (ER), progesterone receptor (PR), and (human epidermal growth factor receptor-2) Her-2 on core needle biopsies (CNBs) is increasingly in use to diagnosis early breast cancer, but its concordance with surgical excision (SE) is not well documented. The study included 100 formalin fixed, paraffin-embedded specimens of invasive breast carcinoma archived in Pathology Department of Cancer Institute, Tehran, Iran, from 2011 to 2014. Immunohistochemistry was applied to detect ER, PR, and Her-2. The current study findings indicated a significant correlation of 90% between CNB and SE specimens for ER expression. The correlation between CNB and SE specimens was estimated as 81% and 97.3% for PR and Her-2, respectively. CNB can be performed confidently to determine ER and Her-2. For PR, results obtained from CNB should be considered.
Highlights
Breast cancer is one of the most frequently diagnosed neoplasms among females (1), and one of the main causes of the mortality and morbidity worldwide (1,2,3)
The current cross sectional, retrospective study was conducted in the second half of 2015 on a total of 100 formalin fixed, paraffin-embedded specimens definitely diagnosed as invasive breast carcinoma archived in Pathology Department of Cancer Institute, Tehran, Iran,from2011 to 2014.Thestudy was approved by the Ethics Committee of Tehran University of Medical Sciences, and the routine paraffin block-included study rules, such as preservation of adequate specimen for further evaluations, were considered
To compare the core needle biopsies (CNBs) with surgical excision (SE) specimens regarding estrogen receptor (ER) expression, 89%of positive CNBs were confirmed by SE specimens and 92%of negative CNBs were followed by the same findings of SE specimens (Table 1)
Summary
Breast cancer is one of the most frequently diagnosed neoplasms among females (1), and one of the main causes of the mortality and morbidity worldwide (1,2,3). Nowadays, increasing screening programs lead to the discovery of clinically occult lesions (3), and death rates decrease due to earlier detection and more effective treatments (4). Since the prediction of tumor behavior is a crucial component for long term follow-up treatment plans, finding clinical or pathologic prognostic parameters is of great value (5). CNB has an undeniable role to diagnose both palpable and impalpable lesions (1,2,6), and provides substantial information to determine the subsequent therapeutic strategies due to the immunohistochemical evaluations of CNB, in the setting of neo adjuvant therapy (6,7). Based on the possibility of heterogeneous distribution of hormonal receptors within tissue, the need for a reliable procedure to accurately depict the tumor hormonal profile arises, and still there is a great debate about the more effective procedures (1,6)
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