Abstract
Evidence is presented to suggest that N- acetyltyramine is the main intermediate on the pathway to N- acetyldopamine when Schistocerca gregaria thoracic ganglia are incubated with either [ 3H]-tyrosine or [ 3H]-tyramine. The subsequent o- hydroxylation of N- acetyltyramine is stimulated by ascorbic acid and inhibited by 5-fluorotryptamine. It appears to be catalysed by an o- hydroxylase with cofactor and substrate specificities different from either mammalian tyrosine hydroxylase or tyrosinases from various sources.
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