Abstract
1. 1. Measurements of light scattering and sedimentation have been made to study the effect of calcium ion at concentrations up to 0.002 M on the dimensions of intermediate polymers of fibrinogen formed in the presence of hexamethylene glycol. The polymer width appears to be unaffected but the length is somewhat increased. 2. 2. The dissociation of such polymers when diluted at constant solvent composition has been followed by light-scattering measurements of the changes of molecular weight and length with time. It is concluded that each polymer molecule breaks up gradually and that the bonds between the fibrinogen units are broken in the middle as well as at the ends of the polymer. Empirically, the average molecular weight decreases with time following a first-order rate law except in the early stages of the process. 3. 3. When the serum factor of Laki and Lóránd is present, increasing concentrations of calcium diminish both the extent and rate of dissociation. It is concluded that the stronger bonds which have been inferred from the properties of fibrin clots prepared in the presence of calcium are formed in the primary polymerization process.
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