Abstract
1. 1. Flow birefringence measurements have been made on solutions in which bovine fibrinogen (4 g./l.) and thrombin (1 unit/ml.) had been allowed to react for various times in the presence of 0.5 M hexamethylene glycol. 2. 2. The dependence of extinction angle on velocity gradient indicates the presence of elongated fibrinogen polymers of various lengths which increase with time of reaction, attaining values of the order of 4000 A. after 1 day. These polymers apparently dissociate into somewhat shorter particles when the protein concentration is reduced by a diluent which contains glycerol. 3. 3. The sign of the birefringence was in all cases positive. The magnitude of the reduced birefringence indicates that a substantial proportion of the fibrinogen is in the form of elongated polymers in these systems.
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