Abstract
Although the standard treatment for ovarian carcinoma with peritoneal metastases is systemic chemotherapy alone or systemic chemotherapy with debulking surgery, a new technique gains more ground: a combination of hipertermic intraperitoneal chemotherapy (HIPEC) and optimal cytoreduction surgery. The proof is mounting regar-ding the benefi ts of HIPEC for patients with metastatic ovarian carcinoma but it still lacks a standard protocol of use. It has increased costs, and incomplete data regarding its safety. Due to these reasons, it is still considered an alternative treatment. Our study aimed to evaluate the published literature regarding this technique from the point of view of safety and effi cacy when compared with the standard of care treatment.
Highlights
Surgery represents the mainstay treatment in early ovarian cancer
Our study aims to confront and compare the recent data published in literature regarding the role of intraperitoneal chemotherapy in ovarian cancer with peritoneal metastasis
The evaluated variables of the selected trials were: the total number of patients included in the studies, clinical information, demographic information, tumor staging, the use of intraperitoneal chemotherapy, and chemotherapeutic agents used, tumor burden
Summary
The lifetime risk to develop ovarian cancer is 1 of 70 women making it one of the most frequent causes of death due to malignancies in women This high frequency coupled with a silent evolution has both drawn increased attention to the diagnosis and treatment in early and advanced stages[2,3]. Corresponding author: Due to the predominant development of these tumors in the peritoneal serosa, a coherent approach would try to treat at this level as the whole peritoneal cavity is accessible by surgery. With this principle in mind, intraperitoneal chemotherapy was developed[4]
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