Abstract
Eating disorders and obesity are important health problems with a widespread global epidemic. Adiponectin (AdipoQ), the most abundant adipokine in the plasma, plays important roles in the regulation of energy homeostasis, glucose metabolism and lipid metabolism. Plasma adiponectin concentration is negatively associated with obesity and binge eating disorder. There is a growing interest in the appetite regulation function of adiponectin. However, the effect of AdipoQ on feeding behavior is controversial and closely related to nutritional status and food composition. In this review, we summarize the literatures about the discovery, structure, tissue distribution, receptors and regulation of nutritional status, and focus on the biological function of adiponectin in the regulation of food intake in the central and peripheral system.
Highlights
Eating disorders and obesity have become public health concerns that negatively affect the physical and mental health of human [1,2,3]
adiponectin receptor 1 (AdipoR1) expression was inhibited by the administration of AdipoR1 siRNA, AdipoQ could not reverse the suppression of AMPK and acetyl-CoA carboxylaze (ACC) phosphorylation caused by leptin [22]
These results suggest that intravenous treatment of AdipoQ at least partly go across the blood–brain barrier acting on AMPK signal pathway in the arcuate nucleus of hypothalamus to promote food intake of rodents, which is the opposite of the action of leptin on food intake
Summary
Eating disorders and obesity have become public health concerns that negatively affect the physical and mental health of human [1,2,3]. Peripheral tissues can perceive (sense) the changes of body energy metabolism, produce a series of appetite-related hormones and transmit appetite signals to the brain to regulate feeding behavior through nerve or endocrine pathways. It is worth nothing that the effect of AdipoQ on food intake is conflicting, including inhibiting food intake [20], promoting food intake [22] and not affecting food intake [23]. This discrepancy might be due to different nutritional status and dietary composition. This review is aimed to summarize the function of AdipoQ on appetite regulation and its relationship with feeding status and nutrients
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