Abstract
In a companion report, an impairment in voice onset time (VOT) control was described for a group of subjects with paraneoplastic cerebellar degeneration who could otherwise produce appropriate segmental duration. The underlying neurophysiological changes were related to regional cerebral metabolic rates for glucose (rCMRGlu) determined by F18-fluorodeoxyglucose/positron emission tomography (PET). Nine cerebellar subjects and 18 normal controls were studied with eyes patched while listening to music and periodic verbal briefings. The rCMRGlu was calculated for each of 28 anatomically defined regions of interest (ROI). The cerebellar subjects could be differentiated from normals by their lower global metabolic rate, and by their rCMRGlu pattern. For those cerebellar subjects who could participate in the acoustic study, cerebellar rCMRGlu was significantly below normal range (p < 0.05) in all but one case. Severity of VOT abnormality appeared to be related not only to cerebellar rCMRGlu, but to abnormally low cortical rCMRGlu as well. The role of the cerebellum in maintaining temporal coordination of articulatory maneuvers appears to involve the coordination of cortical and subcortical brain regions. [Work supported by NS17778 and NS23473.]
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