Abstract
Summary The red cells of the original patient with Hb-Shepherds Bush (Hb-ShB 25%, Hb-A 75%) have a physiologically significant increased oxygen affinity. This is one third due to the intrinsic raised oxygen affinity of Hb-ShB and two-thirds due to its diminished response to 2,3-DPG, there being no interaction between the two haemoglobins present in the cells.
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