Abstract
In the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated. We show that electrographic monitoring is mandatory to enable reliable assessment of status epilepticus control as the number of false positives is extremely high when status epilepticus control is only behaviourally assessed. Diazepam and ketamine synergistically blocked all electrographical seizure activity.
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