Abstract
Iron oxide γ-Fe2O3 magnetic nanoparticles (MNPs) were fabricated by laser target evaporation technique (LTE) and their structure and magnetic properties were studied. Polyacrylamide (PAAm) gels with different cross-linking density of the polymer network and polyacrylamide-based ferrogel with embedded LTE MNPs (0.34 wt.%) were synthesized. Their adhesive and proliferative potential with respect to human dermal fibroblasts were studied. At the same value of Young modulus, the adhesive and proliferative activities of the human dermal fibroblasts on the surface of ferrogel were unexpectedly much higher in comparison with the surface of PAAm gel. Properties of PAAm-100 + γ-Fe2O3 MNPs composites were discussed with focus on creation of a new generation of drug delivery systems combined in multifunctional devices, including magnetic field assisted delivery, positioning, and biosensing. Although exact applications are still under development, the obtained results show a high potential of LTE MNPs to be applied for cellular technologies and tissue engineering. PAAm-100 ferrogel with very low concentration of γ-Fe2O3 MNPs results in significant improvement of the cells’ compatibility to the gel-based scaffold.
Highlights
The development of bioengineering constructions based on polymeric scaffolds and living cells is a promising direction for cellular technologies and tissue engineering [1,2,3,4]
We show that for the same value of Young modulus, the adhesive and proliferative activities of the human dermal fibroblasts cultivated onto the surface of the ferrogel are unexpectedly much higher than those cultivated onto the surface of PAAm gel
One can see that the shape of laser target evaporation (LTE) magnetic nanoparticles (MNPs) is close to spherical
Summary
The development of bioengineering constructions based on polymeric scaffolds and living cells is a promising direction for cellular technologies and tissue engineering [1,2,3,4]. The hydrogel-like scaffolds have a high potential for different applications in the area of regenerative medicine [2,3,5,6,7]. Hydrogels comprise a polymeric network swollen in water [8]. The structure of synthetic hydrogels from many points of view is quite similar to the structure and properties of the biological objects that play an important role in the performance and regulation of various cellular functions [9,10]. Hydrogels belong to the category of “smart” materials, since they can significantly change their volume and shape under change of the external factors of physical or chemical nature [10,11,12,13,14]
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