Abstract
The objective of our research was to examine the dynamics of cytokine profile in the saliva of the children with the pharynx lymphoid ring hypertrophy before and after adenoidectomy and adenotonsillotomy. The study was conducted by the method of solid-phase immunoenzyme analysis for the quantitative determination of cytokines in the saliva. The results of the study were processed using the standard statistical analysis software STATISTICA 12.0. Conclusion: The comparison of the primary results in the groups revealed the following patterns: the content of TNF-α was higher in the patients with the pharynx lymphoid ring hypertrophy, and the content of IL-1b was significantly higher in the patients with adenoids. The content of IL-6 was high both in children with the pharynx lymphoid ring hypertrophy and with adenoids. The content of IL-1b reliably increased in the postoperative period in children after adenotonsillotomy, the content of IL-6 increased after adenoidectomy and adenotonsillotomy, and the content of TNF-a decreased in children after adenoidectomy. Multidirectional changes of cytokines are explained by the imbalance of the cytokine immune response that the children with the pharynx lymphoid ring hypertrophy.
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