The content of fatty acids in blood plasma in men with arterial hypertension (“ESSE-RF3” in the Novosibirsk region)

Abstract

Objective. The aim of the study was to investigate the content of fatty acids (FA) in the blood plasma of Novosibirsk men (“ESSE-RF3” in the Novosibirsk region) with established and newly diagnosed arterial hypertension (HTN). Design and methods. Within the framework of the multicenter single-stage epidemiological study ESSE-RF3 in the Novosibirsk region, 1200 residents of Novosibirsk (men — 600, women — 600) aged 35–74 years were examined. The random number study included 340 men with an average age of 54,63 ± 11,34 years, of which 156 people with established HTN, 49 had AH for the first time, and 135 people without HTN. In the blood plasma, the fatty acid spectrum of blood, including omega‑3,-6,-9 FA, was determined by highperformance liquid chromatography. Results. The level of alpha-linolenic and gamma-linolenic FAs was 1,21 (p = 0,005) and 1,39 times higher (p = 0,013) in the group of men with established HTN (who did not reach the target values of blood pressure against the background of therapy), respectively. The content of gammalinolenic acid was 1,46 times higher in the group of men with the first ever detected HTN (p = 0,038) when compared with the group of men without HTN. The relative chance of HTN in men, regardless of risk factors, is directly associated with an increase in the level of gamma-linolenic FA, and inversely associated with the level of hexadecenoic FA in blood plasma. Conclusions. Thus, from the studied FA in blood plasma, an increase in the level of gamma-linolenic FA can serve as an additional informative biomarker indicating a high probability of developing HTN in men.