Abstract

One phase of any successful totally synthetic approach to the construction of the diterpenoid alkaloids atisine (l)l and garryfoline (2)1'2 must be the elaboration of the C/D bicyclic ring system. While a method for the construction of such ring systems would be premature without the availability of the necessary tetraor pentacyclic substrates on which it could be applied, the recent successes of Edwards3 and Shlmizu4 In this latter endeavor suggests the value of reporting a C/D ring system synthesis at this time.

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