Abstract

AbstractAn unexpected strategy has been discovered for the construction of polysubstituted aromatic core derivatives from the reaction of quinones or N‐substituted maleimides with β‐enamino esters by a cycloaddition/oxidative aromatization sequence that provides products contrary to those delivered by the Nenitzescu reaction. The current method provides a highly favorable synthetic strategy for the efficient construction of important therapeutic agents containing polysubstituted aromatic core structures.magnified image

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