Abstract
PurposeMeasuring quality of life in acute asthmatics is challenging, especially when asthma attacks can occur sporadically. Several questionnaires can be used to measure quality of life in this patient group; however, psychometric testing is limited on questionnaires that can be used to estimate Quality Adjusted Life years. The objective of this study is to assess the construct validity (convergent and discriminative validity) and responsiveness of the EuroQol-5-Dimensions 5-Level (EQ-5D-5L), Asthma Quality of Life Utility Index-5 Dimensions (AQL-5D) and Time Trade-Off (TTO) in acute asthma patients.MethodsData from a prospective cohort study were used to test the validity and responsiveness of the EQ-5D-5L, AQL-5D and TTO in asthma patients who were recruited from UK accident & emergency departments or hospital wards. The spearman’s rank correlation coefficient, the Kruskal–Wallis test statistic and the standardized response mean were used to test for convergent validity, discriminative validity and responsiveness, respectively.ResultsOne hundred and twenty-one participants were included in the available case analysis. The EQ-5D-5L and AQL-5D showed moderate to strong correlations for convergent validity at baseline, week 4 and week 8. The AQL-5D and TTO showed moderate correlations at week 4 and week 8. No statistical significance was observed for discriminative validity at baseline. Both the EQ-5D-5L and the AQL-5D also showed that they were sensitive to change for the recovery responses.ConclusionsThe EQ-5D-5L and AQL-5D showed stronger construct validity and responsiveness compared to the TTO. Therefore, both the EQ-5D-5L and AQL-5D should be considered for use in future economic evaluations.
Highlights
Patient-reported outcome measures (PROMs) are used widely in research as they are useful for capturing patient’s perceptions for different health states [1]
Many different PROMs have been used for asthma studies [3,4,5,6], the Asthma Quality of Life Questionnaire (AQLQ) [7], mini-AQLQ [8], St George’s Respiratory Questionnaire (SGRQ) [9] and EuroQol-5-Dimensions (EQ-5D) [10] being some common ones
The sample size, participant characteristics and attrition rate are similar to other asthma studies which assess the validity of PROMs, which further confirms the representativeness and
Summary
Patient-reported outcome measures (PROMs) are used widely in research as they are useful for capturing patient’s perceptions for different health states [1]. As seen in a previous systematic review [3], the use of PROMs in asthma is extensive. Many different PROMs have been used for asthma studies [3,4,5,6], the Asthma Quality of Life Questionnaire (AQLQ) [7], mini-AQLQ [8], St George’s Respiratory Questionnaire (SGRQ) [9] and EuroQol-5-Dimensions (EQ-5D) [10] being some common ones. As there are so many different PROMs available to use, it is important that there is transparency for their use and knowledge as to which one is more appropriate. There is no current guidance on the most appropriate PROMs for asthma [5]
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