Abstract
Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7–3.68 μM.
Highlights
Michelia (Magnoliaceae) consists of about 30 species, living in subtropical and tropical Asia, from eastern India through the Indo-Chinese Peninsula to Southern China, Southern Japan and southward toMalay Islands
RAW 264.7 cells were incubated with various concentrations of these compounds and LPS (100 ng/mL) for 24 h for detection of nitric oxide (NO) production
High levels of NO produced by inducible nitric oxide synthase have been defined as a cytotoxic molecule in inflammatory process [43]
Summary
Michelia (Magnoliaceae) consists of about 30 species, living in subtropical and tropical Asia, from eastern India through the Indo-Chinese Peninsula to Southern China, Southern Japan and southward to. Michelia species have been used in the treatment of cancer by indigenous peoples. Such as, Michelia champaca has been used in India for the treatment of abdominal tumors as well as Michelia hypoleuca and Michelia officinalis for carcinomatous sores and leukemia respectively, in China. The extract of Michelia champaca leaves has exhibited an anti-inflammatory activity in pro-inflammatory conditions [3]. The bioactive constituents of the heartwood of M. compressa were searched for by assaying the effects on nitric oxide (NO) inhibition in LPS (lipopolysaccharide)-activated mouse peritoneal macrophages and evaluating their cytotoxicity of six human cancer cell lines including human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines
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