Abstract
The consequences of systematic error in enzyme kinetics was considered by introducing a first order error term into the Michaelis-Menten-Briggs-Haldane equation. The situations investigated were those involving over- or undercorrection of an enzyme or substrate blank reaction in the absence and presence of product inhibition and in the presence of a totally competitive, non-competitive or uncompetitive inhibitor. In addition, consideration was given to errors arising from a departure from the Beer-Lambert relationship and those proportional to the velocity or substrate concentration. Finally, attention has been called to the questionable validity of using weighting procedures to correct for random error in the presence of systematic error.
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