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Abstract
Aim. To study the condition of the processes of lipid peroxidation and antioxidant defense of the blood in parturient women with the rheumatic heart diseases depending on the activity of the rheumatic process and the stage of the blood circulation deficiency.Material and methods. The level of lipid hydroperoxides, malonaldehyde, glutathione and glutathione-peroxidase before delivery and in the delivery dynamics in patients with rheumatism and healthy women were studied.Results. More significant intensification of lipid peroxidation has been shown in parturient women with active stage of the rheumatic process than in patients with inactive phase. Thus, the content of lipid hydroperoxides in term II of delivery constituted 1.7±0.2 mcmol/ml erythrocytes and 1.55±0.6 mcmol/ml erythrocytes accordingly. The level of malonaldehyde was 146.8±3.4 mcmol/ml erythrocytes and 135.8±3.5 mcmol/ml erythrocytes accordingly. Herein, the level of the restored glutathione in women with the active phase of the rheumatic process didn’t increase that is evidence of antioxidant insufficiency. The most significant disturbances were observed in parturient women with active phase of the rheumatic process in stage II of the blood circulation deficiency. Glutathione level decrease (24.5± 0.9 mcmol/ml erythrocytes) was observed in these women in term III of delivery in response to intensification of the lipid peroxidation processes in comparison with the parturient women with the stage I of the blood circulation deficiency (36.7±1.3 mcmol/ml erythrocytes, as well as glutathione-peroxidase activity decrease (27.6±1.2 mcmol/ml erythrocytes and 33.9±1.3mcmol/ml erythrocytes accordingly). It is indicative of exhaustion of antioxidant system defense.Conclusions. Pathological increase of lipid peroxidation products in the blood of parturient women with rheumatism in the presence of antioxidant deficiency is evidence of the derangement of the organism adaptation processes to stress situations at delivery.
Highlights
More significant intensification of lipid peroxidation has been shown in parturient women with active stage of the rheumatic process than in patients with inactive phase
Glutathione level decrease (24.5 ± 0.9 mcmol/ml erythrocytes) was observed in these women in term III of delivery in response to intensification of the lipid peroxidation processes in comparison with the parturient women with the stage I of the blood circulation deficiency (36.7 ± 1.3 mcmol/ml erythrocytes, as well as glutathione-peroxidase activity decrease (27.6 ± 1.2 mcmol/ml erythrocytes and 33.9 ± 1.3 mcmol/ml erythrocytes ). It is indicative of exhaustion of antioxidant system defense
3. У рожениц с активной фазой ревматического процесса при II стадии недостаточности кровообращения в ответ на значительную активацию процессов Перекисное окисление липидов (ПОЛ) наблюдалось истощение компонентов антиоксидантной системой (АОС) защиты
Summary
Цель работы – изучить состояние процессов перекисного окисления липидов и антиоксидантной защиты крови у рожениц с ревматизмом в зависимости от активности ревматического процесса и стадии недостаточности кровообращения. Патологическое повышение продуктов перекисного окисления липидов в крови рожениц с ревматизмом при наличии антиоксидантной недостаточности свидетельствует о нарушении процессов адаптации организма к стрессовым ситуациям в родах. Мета роботи – вивчити стан процесів перекисного окислення ліпідів та антиоксидантного захисту крові в роділь із ревматизмом залежно від активності ревматичного процесу та стадії недостатності кровообігу. У цих жінок у ІІІ періоді пологів у відповідь на інтенсифікацію процесів перекисного окислення ліпідів спостерігали зниження вмісту глутатіону (24,5 ± 0,9 мкмоль/мл ер.) порівняно з роділлями з І стадією недостатності кровообігу (36,7 ± 1,3 мкмоль/мл ер.), а також зниження активності глутатіонпероксидази Патологічне збільшення продуктів перекисного окислення ліпідів у крові роділь із ревматизмом за наявності антиоксидантної недостатності свідчить про порушення процесів адаптації організму до стресових ситуацій під час пологів. To study the condition of the processes of lipid peroxidation and antioxidant defense of the blood in parturient women with the rheumatic heart diseases depending on the activity of the rheumatic process and the stage of the blood circulation deficiency
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