The condition of lipid metabolism in patients with newly diagnosed acute leukemia.

Abstract

The article presents comparative analysis of lipid metabolism in patients with acute leukemia depending on form of disease, age, occurrence of cardiovascular pathology and infectious complications. The study sampling included 148 patients with primarily diagnosed acute leukemia aged from 16 to 79 years (average age is 54 years). The control group consisted of 28 healthy volunteers aged from 26 to 75 years (average age is 49 years). The distribution by age in this group corresponded to distribution in group of patients (p>0.05, khi-square). It is established that under acute promyelocyte leukemia indicators of lipid metabolism are subjected to minimum alterations because only concentration of high density lipoproteins reliably decreased. In case of other forms of acute myeloid leukemia and acute lymphoblastic leukemia significant alterations of lipid specter of blood occur characterized by decreasing of content of cholesterol, high and low density lipoproteins and apolipoprotein A1.Also it was established that these alterations have no dependence on age of patients in contrast with healthy individuals having direct dependence of level of cholesterol and high and low density lipoproteins on age. The occurrence of concomitant cardiovascular pathology in patients with acute leukemia had no effect on indicators of lipid metabolism. The occurrence of infectious complications during period of manifestation of acute leukemia enhances shifts in indicators of lipid transport system in direction of decreasing of levels of cholesterol and high and low density lipoproteins.