Abstract
The pro-inflammatory effects of IL-1β have been linked to the induction of the enzyme COX-2. We now show that in addition to increasing the expression of COX-2, IL-1β concomittantly decreased the expression of lipocortin 1 on the surface of A549 cells. Furthermore, cytosolic PLA 2is concomittantly activated by phosphorylation—resulting in a stimulation of arachidonic acid and PGE 2release. All of these effects appear to be mediated via a common pathway of PLC and PKC activation. Activation of cPLA 2is inhibited by dexamethasone in a lipocortin 1-dependent mechanism. We present a novel hypothesis whereby the effects of IL-1β are not only due to activation of enzymes necessary for generation of eicosanoids but also to an inhibition of mechanisms that regulate the supply of arachidonic acid.
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