Abstract
Radionuclide therapy depends for success on the critical relationship between the amount of radionuclide in the target tissue and in critical normal tissue. The successful implementation of radioimmunotherapy for treatment of cancer has proven to be considerably more difficult than initially anticipated. Several groups have tried the magnetic guidance of antiplastic and antibacterial agents as well as X-ray-and MRI-contrast substances by means of magnetic particles. We propose to use magnetic nanospheres for the directed delivery of radionuclide to the tumor after intravenous administration of the biodegradable colloidal suspension. Using carriers of this size range the circulation time in the blood, the biodistribution and more or less the specific targeting are determined by uniformity of size, chemical composition, surface modification and the electric surface charge. The electrophoretic mobility is an important parameter for the prediction of the usefulness of the prepared particle, modified by chemical and biological molecules.
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