Abstract
Epilepsy comprises more than 40 clinical syndromes affecting millions of patients and families worldwide. To decode the molecular and pathological framework of epilepsy researchers, need reliable human epilepsy and control brain samples. Brain bank organizations collecting and supplying well-documented clinically and pathophysiologically tissue specimens are important for high-quality neurophysiology and neuropharmacology studies for epilepsy and other neurological diseases. New development in molecular mechanism and new treatment methods for neurological disorders have evoked increased demands for human brain tissue. An epilepsy brain bank is a storage source for both the frozen samples as well as the formaldehyde fixed paraffin embedded (FFPE) tissue from epilepsy surgery resections. In 2014, the University of Saskatchewan have started collecting human epilepsy brain tissues for the first time in Canada. This review highlights the necessity and importance of Epilepsy Brain bank that provides unique access for research to valuable source of brain tissue and blood samples from epilepsy patients.
Highlights
History of Brain Banks in CanadaThe pioneer of brain banking in Canada was Dr Ali Rajput at the University of Saskatchewan
Up to 50% of patients with epilepsy suffer from behavioral co-morbidities such as impaired cognition, anxiety, and depression, which can often be more debilitating for the patients than the seizures themselves [8]
36% of patients with epilepsy do not respond to medication but this percentage is even higher for patients with Temporal Lobe Epilepsy (TLE), where 70% of patients typically do not benefit from current drug treatments [11]
Summary
Lizbeth Hernandez-Ronquillo 1, Hajar Miranzadeh Mahabadi 2, Farzad Moien-Afshari 3, Adam Wu 4, Roland Auer 5, Viktor Zherebitskiy 5, Ron Borowsky 6, Marla Mickleborough 6, Richard Huntsman 7, Mirna Vrbancic 8, Francisco S. To decode the molecular and pathological framework of epilepsy researchers, need reliable human epilepsy and control brain samples. Brain bank organizations collecting and supplying well-documented clinically and pathophysiologically tissue specimens are important for high-quality neurophysiology and neuropharmacology studies for epilepsy and other neurological diseases. New development in molecular mechanism and new treatment methods for neurological disorders have evoked increased demands for human brain tissue. An epilepsy brain bank is a storage source for both the frozen samples as well as the formaldehyde fixed paraffin embedded (FFPE) tissue from epilepsy surgery resections. In 2014, the University of Saskatchewan have started collecting human epilepsy brain tissues for the first time in Canada. This review highlights the necessity and importance of Epilepsy Brain bank that provides unique access for research to valuable source of brain tissue and blood samples from epilepsy patients
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