Abstract
The spondyloarthritis (SpA) is a group of chronic inflammatory rheumatic diseases in association with HLA-B27. They share the clinical features including sacroiliitis, spondylitis, oligoarthritis, enthesitis and extra-articular involvement. Recently ASAS proposed new classification criteria sets of axial and peripheral SpA. They were designed to include non-radiographic SpA, thus can guide the early diagnosis of disease before the structural damage occurs. SpA has a strong genetic predisposition. Non-MHC genes, such as IL23R and ERAP1, as well as HLA-B27 were confirmed as susceptibility genes through several GWAS. Major pathology in SpA is entheseal inflammation and new bone formation. Intrinsic ability of HLA-B27 to trigger innate immune response and several proinflammtory cytokines may contribute to the inflammation in SpA. New bone formation could be explained by a mechanism, partly or completely independent of the inflammatory process. (Korean J Med 2013;85:229-239) Keywords: Spondyloarthritis; Ankylosing spondylitis; Inflammatory back pain; HLA-B27 ì¤ì¬ ë¨ì´: ì²ì¶ê´ì ì¼; ê°ì§ì± ì²ì¶ì¼; ì¼ì¦ì± ë±íµì¦; HLA-B27
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