The concentrations of IL-22, sFas and sFasL in HCV, HIV and HCV/HIV infections

Abstract

IL-22 is a cytokine regulates acute phase protein synthesis, inhibits the processes of necrosis and apoptosis and activates damaged hepatocytes repair. The aim of the study was to assess the concentrations of IL-22, sFas and sFasL in sera of HCV, HIV, HCV and HIV infected patients. The study included 21 HCV, 27 HIV and HCV and 10 HIV infected patients. The highest IL-22 concentration was detected among HIV infected patients with no HCV infection (33.5 pg/ml), and the lowest among HCV infected patients before antivirus treatment (10.9 pg/ml). The concentration of sFasL was significantly higher among HIV infected patients in comparison to those infected with HCV (0.37 pg/ml vs. 0.03 pg/ml). A significant relationship between the concentration of IL-22 and the concentration of sFasL (r = 0.429; p < 0.0006) was observed. Antivirus treatment of HCV infected patients resulted in an increase in the concentrations of IL-22 (10.9 pg/ml vs. 15.2 pg/ml, p < 0.03). We did not observed correlation among concentration IL-22, sFas, sFasL, and viraemias of HCV or HIV. A high concentration of IL-22 and sFasL is detected among HIV infected patients. The IL-22 is an index of improvement of liver function in period of therapy interferon maybe.