Abstract
Abstract By blocking the destruction of serotonin with added ascorbic acid reproducible concentrations of serotonin in the serum are obtained, and a substantial recovery of serotonin added to whole blood can be demonstrated. The mean concentration of serum serotonin by this method in 50 normal persons was 0.21 μg per milliliter, with a range of 0.10 to 0.32 μg per milliliter (± 2 S.D.). Previously noted low and variable concentrations of serotonin in serum are believed to be due to substantial destruction of serotonin prior to assay.
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