Abstract
In clinically healthy Holstein cows (n=25), the dynamics of hormonal metabolism in the first trimester of cow pregnancy was studied. For this purpose, the concentration of kisspeptin, 17β-estradiol, progesterone and cortisol was determined in the blood serum of cows. The animals were regularly monitored with clinical and obstetricgynecological studies. The level of kisspeptin in the first trimester of pregnancy increased almost throughout the entire period under consideration with a decrease in concentration to 194.23±23.61 pg/ml on day 98. The level of estradiol during the first trimester increased from 49.66±9.68 to 76.20±17.84 pg/ml, respectively, which is also explained by the inclusion of the fetoplacental complex in its synthesis and secretion. Progesterone and cortisol levels were on average at the same level. During the experiment, out of 25 animals, embryonic death was recorded in 14 on the 30th day after insemination. As a result, two groups were formed: the 1st group - animals with a normal course of pregnancy and the 2nd group with embryonic death. Analyzing the data of enzyme immunoassay in animals of the 1st group, one can note a decrease in the level of kisspeptin by 11% on the 28th day compared to the 14th day after insemination. At the same time, the concentration of estradiol, on the contrary, increased by 29%. In the second group, on the contrary, the level of kisspeptin and estradiol did not change and, on average, remained almost at the same level. On the 28th day after insemination in the first group, the cortisol concentration was significantly higher compared to the second group - 15.32±3.23 and 9.00±0.89 nmol/l, respectively. Data for kisspeptin and estradiol showed no significant differences. However, it is of interest that in the first group, with an increase in the level of estradiol, a decrease in the level of kisspeptin occurs. In particular, this is consistent with previous studies, according to which such an interaction of these hormones can be regulated by a high concentration of progesterone.
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